![]() 6 Important cell types for skin and tissue regeneration are fibroblasts, keratinocytes, and immune cells (mast cells, neutrophils, and macrophages), which can be stimulated using specific wavelengths with significant tissue penetration properties. ![]() Its action mechanisms encompass increased cellular proliferation, migration, and adhesion. 3–5 In contrast to traumatic ablative (e.g., laser resurfacing) and non-ablative (e.g., intense pulsed light ) skin rejuvenation modalities that induce secondary tissue repair by causing controlled damage to either the epidermis or the dermis, PBM is atraumatic, and bypasses the initial destructive step by directly stimulating regenerative processes in the skin. 1 Because of the combination of high degree of penetration in skin 2 and absorption by respiratory chain components, light in the spectral range from 600 to 1300 nm is useful for promoting wound healing, tissue repair, and skin rejuvenation. However, both novel light sources that have not been previously used for PBM have demonstrated efficacy and safety for skin rejuvenation and intradermal collagen increase when compared with controls.Ī ltering cellular function using low level, non-thermal LED light is called photobiomodulation (PBM) or low-level light therapy (LLLT), and is a medical treatment modality of increasing clinical importance. Conclusions: Broadband polychromatic PBM showed no advantage over the red-light-only spectrum. The blinded clinical evaluation of photographs confirmed significant improvement in the intervention groups compared with the control. Results: The treated subjects experienced significantly improved skin complexion and skin feeling, profilometrically assessed skin roughness, and ultrasonographically measured collagen density. The data collected at baseline and after 30 sessions included blinded evaluations of clinical photography, ultrasonographic collagen density measurements, computerized digital profilometry, and an assessment of patient satisfaction. Irradiances and treatment durations varied in all treatment groups. Of these volunteers, 113 subjects randomly assigned into four treatment groups were treated twice a week with either 611–650 or 570–850 nm polychromatic light (normalized to ∼9 J/cm 2 in the range of 611–650 nm) and were compared with controls ( n=23). Materials and methods: A total of 136 volunteers participated in this prospective, randomized, and controlled study. ![]() Because the action spectra for tissue regeneration and repair consist of more than one wavelength, we investigated if it is favorable to apply a polychromatic spectrum covering a broader spectral region for skin rejuvenation and repair. However, lasers and LEDs may offer some disadvantages because of dot-shaped (punctiform) emission characteristics and their narrow spectral bandwidths. Background data: For non-thermal photorejuvenation, laser and LED light sources have been demonstrated to be safe and effective. Objective: The purpose of this study was to investigate the safety and efficacy of two novel light sources for large area and full body application, providing polychromatic, non-thermal photobiomodulation (PBM) for improving skin feeling and appearance.
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